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- Biogenesis - Simulates evolution with various creatures mutating and evolving so they can better survive. The user can create custom creatures and can influence the environment by nourishing certain organisms.
- Boxcar 2d - Similar to Biogenesis, except that different cars evolve to go the furthest distance in the shortest amount of time.
- EVE online
- Kerbal Space Program - A relatively simple space sim with newtonian physics and custom spaceship construction.
- Lunar Flight
- Moonbase Alpha
- Orbiter Space Simulator
- Piette's falling sand game
- Powder toy - Gives the user a big toybox of elements and lets him play with them as he wishes.
- Spacechem - A puzzle game that tests and teaches basic concepts of computer engineering.
- SpaceEngine - A space exploration game where one can explore the entire Virgo supercluster.
- Space Station 13